Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture

Created: 2021-08-09T00:36:56-05:00

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> We tested the effects of milk thistle (Silybum marianum) extract on the differentiation and survival of cultured neural cells. Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death.