the review session

oopsy mother fucking doopsy

for epilepsy: either want to decrease glutamate which is excitation or increase gaba which is inhibition

don't worry abotu drug understand concept; want glutamate blocker

or gaba agonist

takes longer to regenerate a neuropeptide

6:24

nitric oxide synthase makes nitric oxide

heme oxidase makes co

gc makes cgmp which has effects on cell

don't know mech

both are good vasodilators

fuck i'm wasted rn lmao i came an hour late because it was set an hour early today ahahahahaahah

co does vasodilation and v inflammation; not really understood

anatomy of eye in lab; probably won't ask about it tho

myopia: focuses too close

hyperopia: behind retina

astigmatism: misshapen

presbyopia: won't bend

photoreceptors in back b/c need to be perfused

circadian rhythm:

melatonin lowest during day; highest during night

few of ganglia do melanopsin; light --> scn --| pineal --> melatonin

pupillary reflex [11:00]

edinger-westphal nucleus --> cn iii --> pupil

cones most prominent by fovea

rods around that

fovea moves all the stuff in front of photoreceptors out of way and the ganglia and stuff

optic disk has no fucking shit bla fuck

rods longer and have more photo pigment

d a r k c u r r e n t

i don't think i've been using headers thus far lmao oops

i'm like raelly seriously drunk now but nobody is catching on as far as i can tell

i'm drinking jack directly from my travel coffee mug

someone else came in late which is why i didn't just leave; he basically just restarted the entire review bc the other people who came on time where done

gα subunit --> pde --| cgmp --> channel --> depol

so gα subunit hyperpolarizes the cell

need to convert trans to cis back to reprime the rhodopsin

need to know abc casette; transporter for retinal

brings back

rpe65 converst from trans to cis

after that juts sort of goes back into photoreceptor and rhodopsinnnn

sin

i am isn

alyyy

rods more sensitive but photobleach really easily

dark adaptation is used to bright --> dark: dark current is open and decreasing dark current to adjust

light adap used to dar k--> light: ^^^ dark currrent

too dark --> ca because dark current open;;; want to decrease ca coming in so want to vvv dark curr;

ca has 3 targets: prevents cgmp binding; breaks down cgmp by inhibiting rhodopsin kinase which inhibits transducin which activates pde which breaks down cgmp; prevents synth of cgmp by gc

[prof] might ask to produce curve on slide 24 lol this is useless to you

abc brings to [20:00]

p ganglion have 1:1 convergence?? [31];go to ventral stream; 70% ; parvocellular (small)er

m ganglion are from rods/ocnes::::::: differnce between something is here is it moving; don't need a ton of acuity; so on dorsal side i guess idk; 10%; magnocellluar

k ganglion are literlaly just blue ahahhaahh even the fuckign review ta wa slike this doesn't fuckign matter fuckign loser

sup collic == blindsight

occipital cortex == can't perceive objects visually

meyer's loop goes laterally == upper side

dorsal radiations == lower side

pathways thign

[35] if lesion oen part of shstem: what kidn of effect

i'm good at nodding my head

have 2pee

am i really going to publish thsi

wlel i did just write fire so i guess it will be really easy; otherwise i wouon't be able to do it drunk but rn i think if i just ype "fire index.gmi" into the cli it will go wild

modality is juts type: smell taste touch vision etc

this is working well like idk how much i'll remember in the mornign but i'm advocating for myself like "you don't think we'll need to know x or y" type shit

if something hurts it won't go away, but when you put your shirt on you feel yourself put it on but then the feel of it being there just goes away afterward , ya kjnowwwww

noxious more slowly adapting

squaere is less adapting i think

firing frequency / time is the graph wher that holds

28:45 where are the types of taste buds?????

cn

fungiform 7

foliate 7/9

circumvallate 9

epiglottis 10

type 1 pretty glial: get rid of excess nt etc etc

type 2: sweet umami bitter dep on whcih type of receptors they have

type 3 sour but we didn't really deal with it

umami = t1r1/3

sweet = t1r2/3

bitter = t2r*

"sour he'll get into next time"

in mice saltty is enac but we don't know in humans so fuck this whole-ass line oh but he asked about this on the last exam so salt = enac in rodents[!!!]!!!!!

enac lets sodium in so it can be detected

[22] he's going to ask literally this entire fuckign slide

fuck

ip3 releases calcium but pka prevents that

M E C H A N I S M O F T R A NS D U C T I O N I N T ! R AND T @ R

FUCK

NOT FUCKING IT

FIXING

normall in cell u have some level of camp --> pka --| ip3

but when uactivate this, gα --> pde --| camp so fuck camp fuck pka hell ya @ ip3 ya boy do ya thinggg ip3333

trpm5 is ca dependent and lets in na

which depols and activates even more na channels --> atp release by calhm1 and pannexins or gap junctions

next slide same thing """"but a little more confusing""""

atp --> p2x/p2y

adp --> p2y

type2/3 can crosstalk and they have autoreceptors

fuck details but hell ya @ that shit b/c we really don't know a lot of the details

knowledge: table w/ 4 columns for diff tiss types

know the content you fucker aa

review session over

ooiwajeifoawejf

ok so im pretty sure i didn't dox myself in this file so im just gonna full send it so i can read it whiel i'm intoing food goodbye for nowf